Isolation and in vitro cultivation turns cells from exocrine human pancreas into multipotent stem-cells

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

Jennifer Nichols, Branko Zevnik, Konstantinos Anastassiadis et al. · Cell · 1998 · 3.4K citations · Full text

Embryonic Stem Cell, Induced Pluripotent Stem Cell, Developmental Biology +10

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Yuval Dor, Juliana Brown, Olga I. Martinez et al. · Nature · 2004 · 2.2K citations · Full text

Stem-cell Differentiation, Cell Lineage, Developmental Biology +10

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

R. Lindsay Williams, Douglas J. Hilton, Shirley Pease et al. · Nature · 1988 · 2K citations

Developmental Biology, Cell Division, Medicine +12

β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas

Xiaobo Xu, Joke D’Hoker, Geert Stangé et al. · Cell · 2008 · 967 citations

Regenerative Medicine, Endogenous Progenitors, Developmental Biology +10

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

Henryk Zulewski, Elizabeth Abraham, Melissa J. Gerlach et al. · Diabetes · 2001 · 787 citations · Full text

Adult Stem Cell, Immunology, Nestin-positive Cells +19