Use of the Chiral Pool – Practical Asymmetric Organocatalytic Strecker Reaction with Quinine

Abstract

Abstract magnified image An efficient, organocatalytic enantioselective synthesis of N ‐arylsulfonyl α‐amino nitriles from the corresponding α‐amido sulfones has been developed. This quinine‐catalyzed Strecker reaction provides the corresponding cyanated products in good yields and enantioselectivities.