Concepedia

Pd(0)-catalyzed benzylic arylation–oxidation of 4-methylquinazolines via sp3 C–H activation under air conditions

Dan Zhao, Min‐Xue Zhu, Yue Wang, Qi Shen, Jian‐Xin Li

Organic & Biomolecular Chemistry · 2013 · 30 citations · 53 references

DOI

Concepts

Abstract

An efficient and selective Pd(0)-catalyzed sp(3) C-H bond arylation-oxidation of 4-methylquinazolines is reported. The method enables the introduction of arylketone at the benzylic position of 4-methylquinazolines without the use of an additional directing group, and atmospheric oxygen is used as the sole oxidant.

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