Basic & Clinical Pharmacology & Toxicology · 2009 · 11 citations · 11 references
MedicineImmunologyPharmacotherapyImmunotherapyInflammationRheumatologyAnti-inflammatory PharmacologyAutoimmune Rheumatic DiseasesInflammatory ArthritisInflammatory Disease PharmacotherapyInflammatory MediatorsRheumatoid ArthritisProinflammatory MediatorsRecombinant Fusion ProteinsRheumatoid Arthritis PharmacotherapyRheumatoid Arthritis TherapyTumor Necrosis Factor Inhibitor TherapyTumor Necrosis Factor Therapy
In the treatment of rheumatoid arthritis, specific drugs targeting disease-related proinflammatory cytokines such as tumour necrosis factor-alpha have been observed to show a positive impact on the clinical course of the disease. One of these drugs, etanercept, is a recombinant soluble fusion protein of tumour necrosis factor-alpha type 2 receptor. Although it has many well-established side effects, up to date there has not been any report of angio-oedema in the literature. Hence, we aimed to present clinical findings of a 59-year-old female patient who received etanercept for rheumatoid arthritis and developed angio-oedema during treatment, and to the discuss side effects of the drug within the context of current literature.
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Autoimmune Diseases Induced by TNF-Targeted Therapies
Manuel Ramos‐Casals, Pilar Brito‐Zerón, Sandra Muñoz et al. · Medicine · 2007 · 737 citations
Horng-An Chen, Kuan‐Chia Lin, Chun-Hsiung Chen et al. · Annals of the Rheumatic Diseases · 2005 · 121 citations · Full text