RSC Advances · 2014 · 24 citations · 42 references
Effective DiscriminationNeurotransmissionOptogeneticsSensory SystemsSelective Visual DetectionGanglion CellBioanalysisProbe MoleculeClinical ChemistryMolecular RecognitionTabun Mimic DcnpHealth SciencesBiochemistryBiophotonicsNervous SystemSingle-molecule DetectionBiomolecular EngineeringPhotoreceptor CellCellular NeurosciencePhysiologyCyanohydrin ReactionNeuroscienceCentral Nervous SystemChemical ProbeMedicine
A new tabun specific visual detection protocol is reported. The chemodosimeter fluorescein-hydroxamate aldehyde undergoes tandem nucleophilic substitution followed by cyanohydrin reaction with DCNP and shows a specific spectroscopic behaviour. The probe molecule clearly distinguishes tabun mimic DCNP over other nerve agent simulants as well as strong electrophiles.
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