A novel quinone antibiotic from Malbranchea cinnamomea TAIM 13T54.

Abstract

A novel quinone antibiotic named malbranicin was isolated from the culture filtrate and mycelium of Malbranchea cinnamomea TAIM 13T54, a thermophilic fungus. The antibiotic was elucidated to be 6-(1-acetylethyl)-2-methoxy-2,5-cyclohexadiene-1,4-dione by spectral analysis. Malbranicin exhibited antimicrobial and cytotoxic activities against Gram-positive bacteria and mammalian cell lines, respectively.