Voltammetric Determination of Proguanil in Malarone and Spiked Urine with a Renewable Silver Amalgam Film Electrode

Abstract

Abstract Electrochemical properties of proguanil were investigated by a voltammetric method (SWV) using a renewable silver amalgam film electrode. The influence of buffer pH as well as potential amplitude, frequency, and step potential was studied. The repeatability, precision and recovery of the developed method were examined. The reduction peak current was used for proguanil voltammetric determination in the range 1×10 −7 –6×10 −6 mol L −1 , LOD =2.9×10 −8 mol L −1 , LOQ =9.7×10 −8 mol L −1 . The standard addition method was used to determine proguanil in a commercial formulation (Malarone) and in spiked urine.