Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis*

Abstract

This long-term animal model demonstrates changes in circulating vasoactive hormones similar to prolonged human sepsis, and decreased pressor sensitivity to norepinephrine. Ex vivo sensitivity to vasopressin agonists was heightened. This model is therefore appropriate for the further investigation of mechanisms underlying vasopressin hypersensitivity, which may include receptor or calcium-handling alterations within the vasculature.

References

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	Year	Citations
Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Michael J. Mulvany, W Halpern Circulation Research HypertensionNormotensive RatsVascular AdaptationVascular PharmacologyPhysiology	1977	2.1K
Vasopressin Deficiency Contributes to the Vasodilation of Septic Shock Donald W. Landry, Howard R. Levin, Ellen M. Gallant, Circulation	1997	973
Beneficial Effects of Short-term Vasopressin Infusion during Severe Septic Shock Bhavesh Patel, Dean R. Chittock, James A. Russell, Anesthesiology	2002	682
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure David Brealey, S Karyampudi, Thomas S. Jacques, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology InflammationSevere SepsisMitochondrial FunctionMitochondrial DysfunctionSkeletal Muscle	2004	454
Circulating vasopressin levels in septic shock Tarek Sharshar, Anne Blanchard, Michel Paillard, Critical Care Medicine	2003	406
Vasopressin pressor hypersensitivity in vasodilatory septic shock Donald W. Landry, Howard R. Levin, Ellen M. Gallant, Critical Care Medicine InflammationPreclinical TherapeuticsHypertensionCritical Care MedicineTranslational Medicine	1997	395
Low-Dose Vasopressin in the Treatment of Vasodilatory Septic Shock Mary Beth Malay, Robert C. Ashton, Donald W. Landry,	1999	387
Depletion of neurohypophyseal content of vasopressin in septic shock* Tarek Sharshar, Robert Carlier, Anne Blanchard, Critical Care Medicine	2002	200
Serum vasopressin concentrations in critically ill patients* Stefan Jochberger, Viktoria D. Mayr, Günter Luckner, Critical Care Medicine	2006	102
Inducible nitric oxide synthase pathway in the central nervous system and vasopressin release during experimental septic shock* Alexandre Giusti‐Paiva, Margaret de Castro, José Antunes‐Rodrigues, Critical Care Medicine	2002	95

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