Regulation of Notch Signaling Activity

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Leif W. Ellisen, Jeffrey Bird, Daniel C. West et al. · Cell · 1991 · 1.7K citations

Chromatin, Cell Lineage, Developmental Biology +9

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan · Nature · 1998 · 1.6K citations

Signal Transduction, Signaling Pathway, Cell Interaction +6

Signalling downstream of activated mammalian Notch

Sophie Jarriault, Christel Brou, Frédérique Logeat et al. · Nature · 1995 · 1.4K citations

Developmental Biology, Signal Transduction, Signaling Pathway +8

A Novel Proteolytic Cleavage Involved in Notch Signaling

Christel Brou, Frédérique Logeat, Neetu Gupta et al. · Molecular Cell · 2000 · 1.1K citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +6

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

Jeff S. Mumm, Eric H. Schroeter, Meera Saxena et al. · Molecular Cell · 2000 · 853 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +10