Concepedia

Protective Effect of 3-ß-Hydroxy-2,3-dihydrowithanolide F against CCl<sub>4</sub>-induced Hepatotoxicity

R. Budhiraja, Karvita Garg, S Sudhir, B B Arora

Planta Medica · 1986 · 37 citations · 0 references

Concepts

Weight BasisAnti-inflammatoryOxysterolBiochemistryMedicineLiver PhysiologyToxicologyHepatotoxicityMarked Protective EffectPharmacologyProtective EffectDrug-induced Liver InjuryToxicological MechanismOxidative Stress

Abstract

Protective effect of 3β-hydroxy-2,3-dihydrowithanolide F against CCl4-induced hepatotoxicity has been assessed and the compound was found to possess marked protective effect. A comparison of the protective properties showed that it is more active than hydrocortisone on a weight basis.