Arthritis & Rheumatism · 1994 · 275 citations · 45 references
Life SciencesGeneticsImmunologyAutoimmunityImmunogeneticsInflammationAutoimmune Disease Susceptibility GenesAutoimmune DiseasesCytokine Gene PolymorphismDisease Susceptibility LociGenetic Susceptibility To AutoimmunitySystemic Lupus ErythematosusDisease Severity DeterminantsDisease Severity EstimationDisease Susceptibility AssociationInterleukin-1 Gene PolymorphismsInterleukin-1 Gene VariantsInterleukin-1 Receptor Antagonist VariantsLupus PhotosensitivitySystemic Lupus Erythematosus Associations
OBJECTIVE: We have previously described associations between an allele of the interleukin-1 receptor antagonist gene (IL1RN) and several inflammatory diseases. In this study we tested the IL1RN gene as a possible marker in patients with systemic lupus erythematosus (SLE). METHODS: Eighty-one SLE patients and 261 ethnically matched control subjects were genotyped by polymerase chain reaction. RESULTS: We found an increase in both frequency and carriage rate of IL1RN*2 in the SLE group. This association strengthened with extensive disease and particularly with the presence of photosensitivity and discoid skin lesions. CONCLUSION: We describe a novel association between IL1RN*2 and SLE. Carriage of the allele seems to influence severity rather than susceptibility to SLE. We postulate that the association of this polymorphism with disease severity is a widespread feature of common inflammatory and autoimmune diseases.
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Molecular cloning: A laboratory manual
Prescott L. Deininger · Analytical Biochemistry · 1990 · 86.2K citations
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan, Alan S. Cohen, James F. Fries et al. · Arthritis & Rheumatism · 1982 · 14.6K citations