ACUTE YELLOW ATROPHY OF THE LIVER FOLLOWING THE TAKING OF CINCHOPHEN

Abstract

Cinchophen (atophan, phenyl-quinoline-carboxylic acid) was introduced by Nicolaier and Dohrn in 1908 for the treatment of gout. Its use is no longer restricted to the increase of uric acid excretion in gout but is quite general as an analgesic, especially in chronic gout and arthritis. In the early part of 1926, Sir Langdon Brown1reported two fatal cases of jaundice following the administration of atoquinol and stated that he knew of two other cases. Evans2reported three cases of toxic jaundice following the use of cinchophen, in one of which there were two separate attacks. One followed the taking of thirty 71/2 grain (0.5 Gm.) tablets. He concludes that an idiosyncrasy is necessary to explain these untoward results. Glover3reports a case following the use of atophanyl with indigestion and jaundice. He found the jaundice to be hemolytic in origin. Willcox4reports that a man, aged