Concepedia

Photoregulated Release of Caged Anticancer Drugs from Gold Nanoparticles

Sarit S. Agasti, Apiwat Chompoosor, Chang‐Cheng You, P. S. Ghosh, Chae Kyu Kim, Vincent M. Rotello

Journal of the American Chemical Society · 2009 · 427 citations · 27 references

DOIFull text

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Concepts

Abstract

An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.

References

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