Concepedia

Identification of four novel phosphorylation sites in estrogen receptor α: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2

Christopher Williams, Aninda Basu, Abeer El-Gharbawy, Latonya Carrier, C. Smith, Brian G. Rowan

BMC Biochemistry · 2009 · 72 citations · 48 references

DOIFull text

Open access

Abstract

These novel ERalpha phosphorylation sites represent new means for modulation of ERalpha activity. S559 represents the first phosphorylation site identified in the extreme C-terminus (F domain) of a steroid receptor.

References

48

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Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation.

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, , +9

Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity.

Pascale Le Goff, Monica M. Montano, David J. Schodin et al. · Journal of Biological Chemistry · 1994 · 455 citations · Full text

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Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.

Simak Ali, Daniel Metzger, Jean‐Marc Bornert et al. · The EMBO Journal · 1993 · 450 citations · Full text

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pp90<sup>rsk1</sup> Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167

Peteranne B. Joel, Jeffrey A. Smith, Thomas W. Sturgill et al. · Molecular and Cellular Biology · 1998 · 343 citations · Full text