Systemic Blastomycosis

Abstract

Case Reports1 July 1961Systemic BlastomycosisRecurrent Neurological Relapse in a Case Treated with Amphotericin BR. G. LOUDON, M.B., CH.B., M.R.C.P.E., ROY A. LAWSON JR., M.D.R. G. LOUDON, M.B., CH.B., M.R.C.P.E.Search for more papers by this author, ROY A. LAWSON JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-139 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDisseminated north american blastomycosis is a relatively rare disease, which is generally fatal if untreated. Lesions may occur in the lungs, skin, genitourinary tract, soft tissues, bones, and central nervous system. The causative organism, Blastomyces dermatitidis, is highly sensitive to amphotericin B in vitro and in the experimental animal (1-3). Various authors have reported good results in cases of disseminated blastomycosis treated with intravenous amphotericin B (2, 4, 5). In the case reported here, the patient apparently made a good recovery from disseminated blastomycosis following a course of amphotericin B, but subsequentlysuffered two neurological relapses, although no neurological signs...References1. GOLDSTOUTPAGANODONOVICK WHAJFR: Amphotericins A and B, antifungal antibiotics produced by a streptomycete. I. In vitro studies, in Antibiotics Annual 1955-1956, Medical Encyclopedia, Inc., New York, 1956, p. 579. Google Scholar2. SEABURYDASCOMB JHHE: Experience with amphotericin B for the treatment of systemic mycoses. Arch. Intern. Med. 102: 960, 1958. CrossrefGoogle Scholar3. DROUHETWILKINSON ER: Activité thérapeutique de l'amphotéricine B dans la blastomycose expérimentale. Ann. Inst. Pasteur 93: 631, 1957. MedlineGoogle Scholar4. HARRELLCURTIS ERAC: The treatment of North American blastomycosis with amphotericin B. Arch. Derm. 76: 561, 1957. CrossrefGoogle Scholar5. BAUMSCHWARZ GLJ: North American blastomycosis. Amer. J. Med. Sci. 238: 661, 1959. CrossrefGoogle Scholar6. LEHANYATESBRASHERLARSHFURCOLOW PHJLCAHWML: Experiences with the therapy of 60 cases of deep mycotic infections. Dis. Chest 32: 597, 1957. CrossrefMedlineGoogle Scholar7. MARTINNICHOLSSVIENULRICH WJDRHJJA: Cryptococcosis. Arch. Intern. Med. 104: 4, 1959. CrossrefGoogle Scholar8. BIDDLEKOENIG AH: An agent effective against cryptococcosis of the central nervous system. Arch. Intern. Med. 102: 801, 1958. CrossrefGoogle Scholar9. FITZPATRICKRUBINPOSER MJHCM: The treatment of cryptococcal meningitis with amphotericin B, a new fungicidal agent. Ann. Intern. Med. 49: 249, 1958. LinkGoogle Scholar10. SCHWARZBAUM JGL: Blastomycosis. Amer. J. Clin. Path. 21: 999, 1951. CrossrefMedlineGoogle Scholar11. CARMODYTAPPEN EJW: Blastomycosis meningitis: report of a case successfully treated with amphotericin B. Ann. Intern. Med. 51: 780, 1959. LinkGoogle Scholar12. SEABURY JH: Personal communication. Google Scholar13. WILSONRUPPWILSON GCWW: The dangers of intrathecal medication. J.A.M.A. 140: 1076, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chanute, KansasReceived for publication March 18, 1960.From the Southeast Kansas Tuberculosis Hospital, Chanute, Kans.Requests for reprints should be addressed to R. G. Loudon, M.B., Woodlawn Hospital, 3819 Maple Avenue, Dallas, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNovel Administrations of AntifungalsRECURRENT CENTRAL NERVOUS SYSTEM BLASTOMYCOSIS IN AN IMMUNOCOMPETENT CHILD TREATED SUCCESSFULLY WITH SEQUENTIAL LIPOSOMAL AMPHOTERICIN B AND VORICONAZOLESecondary Intracerebral Blastomycosis with Giant Yeast FormsNovel modes of antifungal drug administrationMeningoencephalitis Due to Blastomyces dermatitidis: Case Report and Literature ReviewTreatment and experimental therapeutics of blastomycosisCurrent Therapy of Major Fungal Diseases of the LungToxicity of amphotericins on chronic administration to mongrel dogsCentral nervous system coccidioidomycosis: A clinicopathologic study of treatment with and without amphotericin BChronic blastomycotic meningitisCerebrospinal Fluid Alterations Associated with Central Nervous System InfectionsThe spectrum of primary blastomycotic meningitis: A review of central nervous system blastomycosisNorth American blastomycosis in Iowa review of 34 casesAußereuropäische MykosenThe Use of Amphotericin B in Blastomycosis, Cryptococcosis and Histoplasmosis 1 July 1961Volume 55, Issue 1Page: 139-147KeywordsAmphotericinBlastomycosisEczemaMetastasisParalysisParaplegiaProteinsResearch laboratoriesSoft tissuesThorax Issue Published: 1 July 1961 PDF DownloadLoading ...