Sulfoxide Reduction in Relation to Organophosphorus Insecticide Detoxification

Abstract

Carbophenothion sulfoxide, an oxidative metabolite of carbophenothion, is reduced to carbophenothion in the living rat and by an in vitro system containing rat liver enzyme, reduced nicotinamide adenine dinucleotide phosphate, and flavin adenine dinu cleotide phosphate. Reduction of sulfoxides, formed metabolicially from certain commercial organophosphorus insecticides, may be important in ameliorating the toxicity of these compounds.