Concepedia

Simvastatin Reduces Vasospasm After Aneurysmal Subarachnoid Hemorrhage

John Lynch, Haichen Wang, Matthew J. McGirt, James S. Floyd, Allan H. Friedman, Alexander L. Coon, Robert Blessing, Michael J. Alexander, Carmelo Graffagnino, David S. Warner,

Stroke · 2005 · 283 citations · 4 references

DOI

Abstract

The use of simvastatin as prophylaxis against delayed cerebral ischemia after aneurysmal SAH is a safe and well-tolerated intervention. Its use attenuates serum markers associated with brain injury and decreases the incidence of radiographic vasospasm and delayed ischemic deficit.

References

4

Novel Diagnostic Test for Acute Stroke

John Lynch, Robert Blessing, William D. White et al. · Stroke · 2003 · 249 citations · Full text

Simvastatin Increases Endothelial Nitric Oxide Synthase and Ameliorates Cerebral Vasospasm Resulting From Subarachnoid Hemorrhage

Matthew J. McGirt, John Lynch, Augusto Parra et al. · Stroke · 2002 · 242 citations · Full text

S-100 protein plasma levels after aneurysmal subarachnoid haemorrhage

Martin Wiesmann, H. Hagenstr�m, D. Gottmann · Acta Neurochirurgica · 1997 · 128 citations

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Serum von Willebrand Factor, Matrix Metalloproteinase-9, and Vascular Endothelial Growth Factor Levels Predict the Onset of Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage

Matthew J. McGirt, John Lynch, Robert Blessing et al. · Neurosurgery · 2002 · 125 citations