Chemical Communications · 2012 · 35 citations · 35 references
Diversity Oriented SynthesisEngineeringNatural SciencesDiversity-oriented SynthesisPolysubstituted 4-AminopyridinesFacile Domino ReactionOrganic ChemistryMethylamine DerivativesChemistryHeterocycle ChemistrySynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
A novel and facile domino reaction has been developed to synthesize a variety of polysubstituted 4-aminopyridines from α-azidovinylketones, aldehydes and methylamine derivatives in reasonably good yields under mild conditions. Additionally, a possible mechanism is proposed.
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