Nitroxyl and its anion in aqueous solutions: Spin states, protic equilibria, and reactivities toward oxygen and nitric oxide

Vladimir Shafirovich, Sergei V. Lymar

Proceedings of the National Academy of Sciences

Reaction between <i>S</i>-Nitrosothiols and Thiols:  Generation of Nitroxyl (HNO) and Subsequent Chemistry

Patrick Wong, Jinjoo Hyun, Jon M. Fukuto, +4

Biochemistry

Bioorganic ChemistryLipid PeroxidationOrganic ChemistrySubsequent ChemistryChemistry +15

Positive inotropic and lusitropic effects of HNO/NO ⁻ in failing hearts: Independence from β-adrenergic signaling

Nazareno Paolocci, Tatsuo Katori, Hunter C. Champion, +5

Proceedings of the National Academy of Sciences

Nitroxyl anion exerts redox-sensitive positive cardiac inotropy <i>in vivo</i> by calcitonin gene-related peptide signaling

Nazareno Paolocci, Walter F. Saavedra, Katrina M. Miranda, +8

Proceedings of the National Academy of Sciences

Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca ²⁺ Cycling

Carlo G. Tocchetti, Wang Wang, Jeffrey P. Froehlich, +14

Circulation Research

Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning

Pasquale Pagliaro, Daniele Mancardi, Raffaella Rastaldo, +7

Free Radical Biology and Medicine

Early PreconditioningHeart FailureCardiovascular DiseaseMedicinePhysiology +7

Mechanisms of Inhibition of Aldehyde Dehydrogenase by Nitroxyl, the Active Metabolite of the Alcohol Deterrent Agent Cyanamide

Eugene G. DeMaster, Beth Redfern, H. Nagasawa

Biochemical Pharmacology

Aldehyde DehydrogenaseAldo-keto ReductaseBiochemistryReactive Nitrogen SpecieMedicine +6

Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury

Xin L., Feng Gao, Liu Gao-lin, +5

Proceedings of the National Academy of Sciences

Opposite EffectsCardiovascular DiseasePostischemic Myocardial InjuryNitric OxideMedicine +12

Nitroxyl Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674

Steve Lancel, Jingmei Zhang, Alicia M. Evangelista, +5

Circulation Research

Cardiac MuscleLipid PeroxidationRedox BiologyCellular PhysiologyOxidative Stress +16

Rapid and Selective Nitroxyl (HNO) Trapping by Phosphines: Kinetics and New Aqueous Ligations for HNO Detection and Quantitation

Julie A. Reisz, Charles N. Zink, S. Bruce King

Journal of the American Chemical Society

Stable Hno BiomarkersEngineeringOrganic ChemistryChemistryExperimental Pharmacology +17