Synthesis · 2009 · 20 citations · 0 references
Natural SciencesChemistryCatalysisOrganic ChemistryCatalyst DesignCatalyst PreparationCatalyst SynthesisCatalytic MaterialsCatalytic MechanismsCatalytic Reaction EngineeringCatalyst Development For SynthesisCatalyst Synthesis DesignCatalytic Reaction MechanismsCatalytic Synthesis
A facile two-step procedure for the preparation of Takemoto’s catalyst is reported. The thiourea moiety was obtained by condensation of 3,5-bis(trifluoromethyl)aniline with phenyl chlorothioformate and in situ substitution of phenol by trans-1,2-diaminocyclohexane. Subsequent reductive dimethylation using formaldehyde/zinc afforded Takemoto’s catalyst.