Neonatal Organophosphorus Pesticide Exposure Alters the Developmental Trajectory of Cell-Signaling Cascades Controlling Metabolism: Differential Effects of Diazinon and Parathion

Abstract

These findings indicate that OPs alter the trajectory of hepatic cell signaling in a manner consistent with the observed emergence of prediabetes-like metabolic dysfunction. Notably, the various OPs differ in their net impact on peripheral AC signaling, making it unlikely that the effects on signaling reflect their shared property as cholinesterase inhibitors.