Concepedia

Reduced Uterine Indoleamine 2,3‐Dioxygenase Versus Increased Th1/Th2 Cytokine Ratios as a Basis for Occult and Clinical Pregnancy Failure in Mice and Humans

David A. Clark, Sandra M. Blois, Judith Kandil, Bori Handjiski, Justin Manuel, Petra Arck

American Journal of Reproductive Immunology · 2005 · 56 citations · 31 references

DOI

Abstract

Loss of an allogeneic embryo in early pregnancy is more likely to be due to a high Th1/Th2 ratio than loss of putative protection by IDO.

References

31

IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-τ

G. Chaouat, Aines Assal Meliani, J. Martal et al. · The Journal of Immunology · 2005 · 455 citations · Full text

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Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF

Joanne Kwak‐Kim · Human Reproduction · 2003 · 447 citations · Full text

Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy

Andrew L. Mellor, Jayabalan Sivakumar, Phillip Chandler et al. · Nature Immunology · 2001 · 427 citations

, , +8

IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN- <i>tau</i> .

G. Chaouat, Amine Meliani, J. Martal et al. · The Journal of Immunology · 1995 · 414 citations

Cytokine-dependent abortion in CBA x DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase].

DavidA. Clark, G. Chaouat, Petra Arck et al. · PubMed · 1998 · 279 citations

, , +14