Concepedia

Rapid method for detecting monoclonality in B cell lymphoma in lymph node aspirates using the polymerase chain reaction.

J H Wan, Pamela J. Sykes, Svante R. Orell, Alexander A. Morley

Journal of Clinical Pathology · 1992 · 75 citations · 9 references

DOIFull text

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Abstract

Detection of monoclonality in a cell population is strongly suggestive of malignant disease. The simple PCR method presented here should complement conventional cytological and immunological methods for diagnosis of malignancy by lymph node aspirates.

References

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Avoiding false positives with PCR

Shirley Kwok, Russell Higuchi · Nature · 1989 · 3.5K citations

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Amplification of human minisatellites by the polymerase chain reaction: towards DNA fingerprinting of single cells

Alec J. Jeffreys, Victoria Wilson, Rita Neumann et al. · Nucleic Acids Research · 1988 · 496 citations · Full text

Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma.

Michael L. Cleary, J Chao, R Warnke et al. · Proceedings of the National Academy of Sciences · 1984 · 455 citations

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Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient.

Kenneth Nilsson, H. Bennich, S. G. O. Johansson et al. · PubMed · 1970 · 375 citations · Full text

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Monoclonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction.

J H Wan, KJ Trainor, M. J. Brisco et al. · Journal of Clinical Pathology · 1990 · 340 citations · Full text

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