Comparison of the ability of opioid analgesics to increase endogenous opioid-like activity in the cerebrospinal fluid of rabbits

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

F. E. D'Amour, Donn L. Smith · Journal of Pharmacology and Experimental Therapeutics · 1941 · 3.2K citations

Nursing, Pharmacology, Pain Management +14

THE EFFECTS OF MORPHINE, METHADONE AND MEPERIDINE ON SOME REFLEX RESPONSES OF SPINAL ANIMALS TO NOCICEPTIVE STIMULATION

S. T. Irwin, Donald R. Bennett, Leland C. Hendershot et al. · Journal of Pharmacology and Experimental Therapeutics · 1951 · 339 citations

Medicine, Pharmacology, Pharmacotherapy +17

THE EFFECT OF VARIOUS NEUROHUMORAL MODULATORS ON THE ACTIVITY OF MORPHINE AND THE NARCOTIC ANTAGONISTS IN THE TAIL-FLICK AND PHENYLQUINONE TESTS

William L. Dewey, Louis S. Harris, John F. Howes et al. · Journal of Pharmacology and Experimental Therapeutics · 1970 · 339 citations

Medicine, Pharmacology, Neuropharmacology +14

Narcotic antagonists in the benzomorphan series

LouisS. Harris · Naunyn-Schmiedeberg s Archives of Pharmacology · 1964 · 321 citations

Medicine, Medicinal Chemistry, Pharmacology +6