Magnetic resonance imaging of shear wave propagation in excised tissue

Abstract

The propagation of shear waves in ex vivo tissue samples, agar/gel phantoms, and human volunteers was investigated. A moving coil apparatus was constructed to generate low acoustic frequency shear perturbations of 50 to 400 Hz. Oscillating gradients phase-locked with the shear stimulus were used to generate a series of phase contrast images of the shear waves at different time-points throughout the wave cycle. Quantitative measurements of wave velocity and attenuation were obtained to evaluate the effects of temperature, frequency, and tissue anisotropy. Results of these experiments demonstrate significant variation in shear wave behavior with tissue type, whereas frequency and anisotropic behavior was mixed. Temperature-dependent behavior related mainly to the presence of fat. Propagation velocities ranged from 1 to 5 m/sec, and attenuation coefficients of from 1 to 3 nepers/unit wavelength, depending on tissue type. These results confirm the potential of elastic imaging attributable to the intrinsic variability of elastic properties observed in normal tissue, although some difficulty may be experienced in clinical implementation because of viscous attenuation in fat.