Phosphorus, sulfur, and silicon and the related elements · 1997 · 24 citations · 1 references
EngineeringBiochemistryNatural SciencesDiversity-oriented SynthesisOrganic ChemistryGermanium AtomCatalysisSynthetic ChemistryChemistryStereoselective SynthesisAsymmetric CatalysisMannich-type ReactionIntramolecular Catalysis MechanismEnantioselective SynthesisBiomolecular Engineering
Abstract A new kind of Mannich-type reaction involving an intramolecular catalysis mechanism was applied for the synthesis of α-aminogermyl phosphonic esters. It was found that the carbonyl group was activated by the coordination between the oxygen atom and the germanium atom. Different amines were investigated under the same reaction conditions. The structures of the products were determined by 1H, 31P NMR, IR spectra, and elemental analysis.
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