Clinical trial: the effects of a trans‐galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome

TLDR

The study examined whether a novel trans‑galactooligosaccharide prebiotic could alter colonic microflora and relieve symptoms in patients with irritable bowel syndrome. In a 12‑week, single‑centre, parallel‑crossover trial, 44 Rome II‑positive IBS patients were randomized to receive 3.5 g/d, 7 g/d of the prebiotic, or 7 g/d placebo, with weekly symptom scoring and monitoring of fecal microflora, stool form, and quality‑of‑life measures. The prebiotic increased fecal bifidobacteria and, at 3.5 g/d, improved stool consistency, flatulence, bloating, composite symptom scores, and global assessment; at 7 g/d it also improved global assessment and anxiety, demonstrating its potential as a therapeutic agent for IBS.

Abstract

Gut microflora-mucosal interactions may be involved in the pathogenesis of irritable bowel syndrome (IBS).To investigate the efficacy of a novel prebiotic trans-galactooligosaccharide in changing the colonic microflora and improve the symptoms in IBS sufferers.In all, 44 patients with Rome II positive IBS completed a 12-week single centre parallel crossover controlled clinical trial. Patients were randomized to receive either 3.5 g/d prebiotic, 7 g/d prebiotic or 7 g/d placebo. IBS symptoms were monitored weekly and scored according to a 7-point Likert scale. Changes in faecal microflora, stool frequency and form (Bristol stool scale) subjective global assessment (SGA), anxiety and depression and QOL scores were also monitored.The prebiotic significantly enhanced faecal bifidobacteria (3.5 g/d P < 0.005; 7 g/d P < 0.001). Placebo was without effect on the clinical parameters monitored, while the prebiotic at 3.5 g/d significantly changed stool consistency (P < 0.05), improved flatulence (P < 0.05) bloating (P < 0.05), composite score of symptoms (P < 0.05) and SGA (P < 0.05). The prebiotic at 7 g/d significantly improved SGA (P < 0.05) and anxiety scores (P < 0.05).The galactooligosaccharide acted as a prebiotic in specifically stimulating gut bifidobacteria in IBS patients and is effective in alleviating symptoms. These findings suggest that the prebiotic has potential as a therapeutic agent in IBS.