Antimycobacterial Activities from Seagrass Enhalus sp. Associated Bacteria Against Multi Drug Resistance Tuberculosis (MDR TB) Bacteria

Abstract

Tuberculosis (TB) is caused by Mycobacterium tuberculosis and the most important public health problem in the world. In 2012, there were an estimated 8.6 million incident cases of TB globally, and estimeated 67,000 deaths among TB cases in 2012. Indonesia ranks 4th on the list of TB high burden countries in the world with 450,000 cases, estimated cases of MDR TB were 5700 and 65.000 deaths among TB cases in Indonesia, 2011.This research was conducted to isolate and characterize of seagrass Enhalus sp. -associated bacteria that having antimycobacterial activity against multi drug resistant tuberculosis bacteria. There were 9 isolates collected from Enhalus sp. One isolate from Enhalus sp.-associated bacteria were successfully screened for antimycobacterial against tuberculosis bacteria. EKJP9 was found to inhibit the growth of tuberculosis bacteria (MDR TB strain HE, SR, HR). Based on DNA Data Bank of Japan the accession number of EKJP9 is AB851799. It is Bacillus sp.