Neurosurgery · 1978 · 33 citations · 0 references
MedicineNeurological SurgeryNeurosurgeryAnesthesiaDrug ClearanceRegional AnesthesiaFluid TherapyIntracranial PressureIntracranial Pressure MonitoringIntrathecal Drug DeliverySpinal AnesthesiaSpinal Cord PhysiologyCerebrospinal Fluid AnalysisCerebrospinal Fluid DistributionCerebrospinal Fluid Pressure MeasurementIntracranial Pressure PhysiologyLumbar Cerebrospinal Fluid Pressure MonitoringSpinal PharmacokineticsStatistical Significance TestingSubarachnoid Space
The variable rate lumbar subarachnoid infusion technique allows rapid quantitative study of the cerebrospinal fluid (CSF) compartment. Numerous pressure plateaus are studied in a brief time period with a servo-controlled system. The test determines the difference between rates of CSF absorption and formation as a function of pressure. On-line computer data analysis increases experimental efficiency to guarantee statistical significance. Animal and patient data are presented in the report.