The Minimal Important Difference in the 6-Minute Walk Test for Patients with Pulmonary Arterial Hypertension

Abstract

Using both distributional and anchor-based methods, the estimated consensus MID in the 6MWT for PAH is approximately 33 m. These results have important implications for (1) assessing treatment responses from clinical trials and metaanalyses of specific PAH therapy, and (2) sample size calculations for future study design.