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SOME EFFECTS OF PURIFIED HETEROLOGOUS ANTIHUMAN LYMPHOCYTE SERUM IN MAN
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1967
Year
ImmunohematologyImmunologyPathologyImmunophenotypingDermatologyImmunotherapySkin Allograft SurvivalHematologyLymphatic SystemHuman SubjectsExperimental DermatologyLaboratory MedicineCell TransplantationHealth SciencesAutoimmune DiseaseAllergyAutoimmunityImmunologic DiseaseSclerodermaProlonged AbolitionLymphatic DiseaseMedicine
A purified 7S-gamma globulin fraction of a rabbit anti-human lymphocyte serum (RAHLS) has been prepared. This material agglutinates and kills human lymph node cells and peripheral blood lymphocytes in vitro. Human subjects given 7S-RAHLS show transient lymphopenia associated with moderately prolonged abolition of positive delayed skin reactions and modest prolongation of skin allograft survival.