Effect of Bacterial Endotoxins on Glycogen Synthesis.

Abstract

Intraperitoneal injection of Salmonella endotoxin completely inhibited in vivo glycogen synthesis from glucose in the liver of rats. In liver slices of rabbits, there was less glycogen formed in vitro from glucose and pyruvate in the presence of meningococcal endotoxin. The glucose uptake of rat diaphragm in vitro was decreased by Salmonella endotoxin and this inhibition of glucose utilization could be diminished by the addition of insulin.