Concepedia

Simple Protocol for the Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones Using SnCl<sub>2</sub> · 2H<sub>2</sub>O–LiCl as an Inexpensive Catalyst System

M. Shailaja, B. Vittal Rao, Parvathi Neelakantan

Synthetic Communications · 2004 · 19 citations · 20 references

DOI

Concepts

Abstract

Abstract A one‐pot synthesis of the 3,4‐dihydropyrimidin‐2(1H)‐ones catalyzed by tin chloride–lithium chloride combination catalyst system involving three component heteroannular cyclization is reported.

References

20

Preparation, metallation and alkylation of allenyl ethers

S. Hoff, L. Brandsma, J. F. Arens · Recueil des Travaux Chimiques des Pays-Bas · 1968 · 996 citations

, , +9

Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

Karnail S. Atwal, Brian N. Swanson, Steven E. Unger et al. · Journal of Medicinal Chemistry · 1991 · 782 citations

Calcium Entry Blockers and Activators: Conformational and Structural Determinants of Dihydropyrimidine Calcium Channel Modulators

George C. Rovnyak, S. David Kimball, Barbara Beyer et al. · Journal of Medicinal Chemistry · 1995 · 547 citations · Full text

Unprecedented Catalytic Three Component One-Pot Condensation Reaction:  An Efficient Synthesis of 5-Alkoxycarbonyl- 4-aryl-3,4-dihydropyrimidin-2(1H)-ones

Essa Hu, Daniel R. Sidler, Ulf‐H. Dolling · The Journal of Organic Chemistry · 1998 · 498 citations

, , +11

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

George C. Rovnyak, Karnail S. Atwal, Anders Hedberg et al. · Journal of Medicinal Chemistry · 1992 · 449 citations