A screen for mutations in human homologues of mice exencephaly genes <i>Tfap2</i>α and <i>Msx2</i> in patients with neural tube defects

Abstract

Although several new genetic variants were found in TFAP2 and MSX2, no statistically significant association was found between NTD cases and the new alleles or their combinations. Further studies are necessary to finally decide if these gene variants may have acted as susceptibility factors in our individual cases.