Regulation of metallothionein gene expression by oxidative stress and metal ions

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Ken Itoh, Tomoki Chiba, Satoru Takahashi et al. · Biochemical and Biophysical Research Communications · 1997 · 4K citations

Life Sciences, Biochemistry, Molecular Biology +14

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Thomas H. Rushmore, Marcia R. Morton, C.B. Pickett · Journal of Biological Chemistry · 1991 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

Stephen M. Keyse, Rex M. Tyrrell · Proceedings of the National Academy of Sciences · 1989 · 1.3K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

Paul J. Thornalley, Milan Vašák · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1985 · 1K citations

Life Sciences, Radiation Oncology, Toxicology +16

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁  gene

Venugopal Radjendirane, Anil K. Jaiswal · Proceedings of the National Academy of Sciences · 1996 · 1K citations · Full text

Life Sciences, Genetics, Molecular Biology +16