Concepedia

Endoscopic and histologic evidence of persistent mucosal healing and correlation with clinical improvement following sustained infliximab treatment for Crohn's disease

Karel Geboes, Paul Rutgeerts, Ghislain Opdenakker, Allan Olson, Kamlesh B. Patel, Carrie Wagner, Colleen Marano

Current Medical Research and Opinion · 2005 · 129 citations · 35 references

DOI

Abstract

Endoscopic and histologic evidence of mucosal healing was associated with a sustained reduction in the expression of inflammatory markers. Infliximab-induced improvement in the clinical signs and symptoms of Crohn's disease was associated with endoscopic and histologic evidence of sustained mucosal healing.

References

35

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial

Stephen B. Hanauer, Brian G. Feagan, Gary R. Lichtenstein et al. · The Lancet · 2002 · 4.1K citations

, , +5

Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor ? monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis

Ravinder N. Maini, Ferdinand C. Breedveld, Joachim R. Kalden et al. · Arthritis & Rheumatism · 1998 · 1.6K citations

Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease

Paul Rutgeerts, Brian G. Feagan, Gary R. Lichtenstein et al. · Gastroenterology · 2004 · 947 citations

, , +4

Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicentre study. Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du Tube Digestif (GETAID).

J Y Mary, R Modigliani · Gut · 1989 · 875 citations · Full text

Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum

Geert D’Haens, Karel Geboes, Filip Baert et al. · Gastroenterology · 1998 · 862 citations · Full text

, , +6