Synthesis and Liposome Insertion of a New Poly(carboranylalkylthio)porphyrazine to Improve Potentiality in Multiple-Approach Cancer Therapy

Abstract

Liposome insertion of a newly synthesized octa-carboranylhexylthio-porphyrazine (H 2 HECASPz) with potentiality in anticancer multiple therapy was described at molecular and supramolecular level. Host−guest interactions between H 2 HECASPz and the liposome constituents were established and were confirmed by DFT calculations. An approach for the design of new porphyrin-like molecules to be carried by liposome is presented.