Concepedia

Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1

Patrick Mougenot, Claudie Namane, E. R. Fett, F. CAMY, Rommel Dadji-Faïhun, Gwladys Langot, Catherine Monseau, Bénédicte Onofri, François Pacquet, Cécile Pascal,

Bioorganic & Medicinal Chemistry Letters · 2012 · 25 citations · 13 references

DOIFull text

Open access

Concepts

References

13

Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

Richard D. Cramer, David E. Patterson, Jeffrey D. Bunce · Journal of the American Chemical Society · 1988 · 3.9K citations

, , +14

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

Sylvaine Cases, Steven J. Smith, Yao-Wu Zheng et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations · Full text

, , +17

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

Steven J. Smith, Sylvaine Cases, Dalan R. Jensen et al. · Nature Genetics · 2000 · 902 citations

, , +17

Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members

Sylvaine Cases, Scot J. Stone, Ping Zhou et al. · Journal of Biological Chemistry · 2001 · 801 citations · Full text

, , +17

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1

Hubert C. Chen, Steven J. Smith, Zuleika Ladha et al. · Journal of Clinical Investigation · 2002 · 294 citations · Full text

, , +17