The Analyst · 1993 · 118 citations · 18 references
Natural SciencesMaterials EngineeringMaterials ScienceBiomaterialsPolymer ChemistryPolymer MaterialsPolymer FunctionalizationPolymer SurfacesPolymeric BiomaterialsProtein-based BiomaterialsSurface ModificationSurface Modification Of BiomaterialsPolyethylene TerephthalatePolymer Grafting Onto SurfacesPolymer ModificationPolymer Surface ModificationSilanizationSurface CoverageSurface Coverage AnalysisSurface Silanization
X-ray photoelectron spectroscopy was used to characterize modified surfaces of a biomedically important polymer, poly(ethylene terephthalate). Several modification schemes were investigated and direct silanization with 3-aminopropyltriethoxysilane was found to be the optimum procedure, resulting in an aminated surface. Surface coverage of up to 100% was achieved with retention of the polymeric structural integrity. Further activation of the silanized surface was accomplished with two cross-linkers, glutaraldehyde and sebacoyl chloride. A simple biomolecule, L-cysteine, was successfully immobilized onto a surface pre-treated with 3-aminopropyltriethoxysilane and glutaraldehyde, with a coverage of 42%.
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