THE EFFECTS OF A NEW BETA‐ADRENOCEPTIVE RECEPTOR BLOCKING DRUG ON HEART RATE IN MAN

Abstract

In 1906, Dale showed that although ergot was capable of preventing most of the excitatory effects of adrenaline and of sympathetic nervous stimulation it was unable to prevent their inhibitory actions. He explained his and Dale's findings by postulating the existence of two types of adrenoceptive receptor which he named alpha and beta.