Organic Letters · 2012 · 46 citations · 21 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryAlkaloid BiosynthesisNatural Product Drug DiscoveryOrganic SynthesisIndole AlkaloidsPlant Alkaloids
A rapid synthesis of the tetracyclic core of Kopsia indole alkaloids related to lapidilectine B, grandilodine C, and tenuisine A is reported. Key to the success of this route was an efficient and scalable Ugi four-component coupling to install all the necessary carbons found in the natural products.
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Oxidation of α,β-un saturated aldehydes
Balkrishna S. Bal, Wayne E. Childers, Harold W. Pinnick · Tetrahedron · 1981 · 1.1K citations
Tobias Seiser, Tanguy Saget, Duc N. Tran et al. · Angewandte Chemie International Edition · 2011 · 590 citations · Full text
B. Lindgren, Torsten Nilsson, Steinar Husebye et al. · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1973 · 506 citations · Full text