Cembranoid diterpenes and a briarane diterpene from corals

Abstract

Two new cembrane diterpenes (+)-polydactylide (1) and (+)-7alpha,8beta-dihydroxydeepoxysarcophine (2) together with (+)-sarcophine (3) and (+)-sarcophytoxide (4) have been isolated from the soft coral Sinularia polydactyla. The new cembrane diterpene (-)-7beta-hydroxy-8alpha-methoxydeepoxysarcophine (5) has been obtained from the soft coral Sarcophyton trocheliophorum and the known briarane diterpene briaexcavatolide W (6) from the gorgonian coral Briareum sp.The structures were determined primarily by NMR spectroscopy. The assignment of NMR signals was performed by means of (1)H-(1)H COSY, ROESY, HMQC and HMBC experiments.