Laboratory Diagnosis of HSV and Varicella Zoster Virus Infections

Abstract

HSV and varicella zoster virus (VZV) are common pathogens of skin and mucous membranes and the CNS. Their rapid and accurate diagnosis is essential for their treatment as well as infection control. Cytological and morphological examination, specific antibody detection methods and virus isolation all have their own limitations in clinical practice. In recent years, molecular methods have become the primary diagnostic methods for the detection and differentiation of HSV1/2 and VZV due to their high sensitivity, specificity, rapid test turnaround time and potential for high throughput and automation. Although molecular assays detect HSV1/2 and VZV more quickly, the clinical significance of positive results may vary in individual patients.