Concepedia

Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine

Iain Coldham, Jignesh J. Patel, Sophie Raimbault, David Whittaker

Chemical Communications · 2007 · 23 citations · 12 references

DOI

Abstract

Asymmetric substitution of 2-lithiopiperidines can be achieved by dynamic resolution; the organolithium is formed as a racemic mixture by proton abstraction (or tin-lithium exchange) and is resolved in the presence of a chiral ligand.

References

12

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Complex Induced Proximity Effects: Enantioselective Syntheses Based on Asymmetric Deprotonations of N-Boc-pyrrolidines

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Configurational Stability and Transfer of Stereochemical Information in the Reactions of Enantioenriched Organolithium Reagents

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Dynamic Thermodynamic Resolution:  Control of Enantioselectivity through Diastereomeric Equilibration

Peter Beak, David R. Anderson, M. David Curtis et al. · Accounts of Chemical Research · 2000 · 196 citations

, , +15