Regulation of type 1 angiotensin II receptor and its subtype gene expression in kidney by sodium loading and angiotensin II infusion

Abstract

A high salt intake downregulates the AT1B mRNA expression but does not change the AT1A mRNA expression and AT1 receptor density in the kidney, suggesting that differential regulation occurs in the kidney. Infusion of a nonpressor dose of Ang II, either alone or in conjunction with a high salt intake, downregulates the AT1 receptor and its subtype gene expression in the kidney, suggesting that Ang II regulates these responses through a negative feedback mechanism.