Outflow Tract Ablation Using a Conditionally Cytotoxic Feline Immunodeficiency Viral Vector

Abstract

A vector-based system for inducible ablation of cells of the outflow tract was developed. Trabecular meshwork ablation lowered IOP, and recovery of cellularity and IOP followed. This model may be useful to study pressure regulation by the TM, its stem cells, and migration patterns.