American Journal of Health-System Pharmacy · 2006 · 105 citations · 53 references
Depression in youth is common and treatable and responds best to multimodal treatment combining patient and family education, cognitive behavioral therapy, and antidepressant medication. The potential benefits of antidepressants outweigh the risks for adolescents. Family and psychotherapeutic interventions are most effective for prepubertal children.
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi, Karen Sugden, Terrie E. Moffitt et al. · Science · 2003 · 8.1K citations
Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression
John S. March, Susan G. Silva, Stephen Petrycki et al. · JAMA · 2004 · 1.7K citations · Full text