Concepedia

An Efficient Amination Method for Manufacturing Cytidines

Hironori Komatsu, Kunihiko Morizane, Toshiyuki Kohno, Hiroharu Tanikawa

Organic Process Research & Development · 2004 · 11 citations · 10 references

DOI

Concepts

Abstract

A novel method for amination of uridine derivatives was developed and applied to the syntheses of cytidines. The method consists of an activation step with 1-methylpiperidine at the C4-position of a uracil base. Large-scale preparation of 2‘-deoxycytidine was performed using this method.

References

10

Practical and efficient methods for sulfonylation of alcohols using Ts(Ms)Cl/Et3N and catalytic Me3H·HCl as combined base: Promising alternative to traditional pyridine

Yoshihiro Yoshida, Yoshiko Sakakura, Naoya Aso et al. · Tetrahedron · 1999 · 154 citations

, , +8

Reaction between 1-arenesulphonyl-3-nitro-1,2,4-triazoles and nucleoside base residues. Elucidation of the nature of side-reactions during oligonucleotide synthesis.

Colin B. Reese, Aiko Ubasawa · Tetrahedron Letters · 1980 · 129 citations

, , +7

Synthesis of 4-(1,2,4-triazol-1-yl)-pyrimidin-2(1H)-one ribonucleotide and its application in synthesis of oligoribonucleotides

Wing L. Sung · The Journal of Organic Chemistry · 1982 · 84 citations

, , +14

General method for the preparation of N3- and O4-substituted uridine derivatives by phase-transfer reactions

Mitsuo Sekine · The Journal of Organic Chemistry · 1989 · 64 citations

, , +15

Stereoselective Synthesis of Anomers of 5-Substituted 2′-Deoxyuridines

H Aoyama · Bulletin of the Chemical Society of Japan · 1987 · 61 citations · Full text

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