Polymorph Selection:  Challenges for the Future?

Abstract

This contribution reviews the area of polymorph selection during solution crystallization using known and predicted structures. In particular, an overview of what has been learned about the relationship between structure and kinetics and of the interplay between thermodynamics and kinetics is presented. This review adds to the debate by discussing the future challenges that we envisage in realizing polymorph selection as a crystal engineering exercise by highlighting the role that a packing landscape approach may contribute in manipulating the selection of a polymorph.