New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

Robert Schwarcz, William O. Whetsell, Richard M. Mangano · Science · 1983 · 1.3K citations

Life Sciences, Neurobiology, Neuroscience +16

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

Jason C. O’Connor, Mark A. Lawson, Caroline André et al. · Molecular Psychiatry · 2008 · 1.3K citations · Full text

Medicine, Neuroscience, Pharmacology +14

The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications

Corey J. Hilmas, Edna F. R. Pereira, Manickavasagom Alkondon et al. · Journal of Neuroscience · 2001 · 853 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Quinolinic acid: A potent endogenous excitant at amino acid receptors in CNS

Trevor W. Stone, M.N. Perkins · European Journal of Pharmacology · 1981 · 756 citations

Life Sciences, Neuroscience, Pharmacology +13

INTENSIFICATION OF THE CENTRAL SEROTONINERGIC PROCESSES AS A POSSIBLE DETERMINANT OF THE THYMOLEPTIC EFFECT

I. P. Lapin, Gregory F. Oxenkrug · The Lancet · 1969 · 710 citations

Life Sciences, Endocrinology, Physiology +16